JOIN US: Become a Member of GEoPD
GEoPD is a global consortium of researchers dedicated to promoting education, scientific research and translational development in Parkinson’s disease.
The consortium has been operating since 2004, and has an active membership from more than 60 sites on 6 continents. The GEoPD is organized by five Cores (Click each heading to review core mandates):
Core Leaders: Manu Sharma, Lars Bertram
The Bioinformatics/Genomics core will integrate, disseminate, store and archive candidate gene(s) and next generation sequencing data generated by different GEoPD sites. Furthermore, the core will integrate data generated by different cores (i.e. Epidemiology core, Clinical core, Biology core) with genomic data to perform multidimensional clinico-genetic-epidemiological studies.
The core will streamline genotype/sequence data and make it available to the GEoPD community for research projects.
The objective of the core is to develop a standardized analytical pipeline to seamlessly perform downstream genomic analyses which will use either next-generation sequencing data (exome, genome, resequencing) or candidate SNP data generated via different genotyping platforms. Furthermore, the core will be responsible for developing and managing the “GEoPD database” which will be accessible to the GEoPD members.
Core Leaders: Matt Farrer, Nobutaka Hattori,Jan Aasly
The Biology core is to compile a resource of expertise, resources and reagents within the GEoPD Consortium. Its objectives are to facilitate research by members of the GEoPD Consortium and to encourage multi-site collaborations.
The descriptors expertise, resources and reagents may be subdivided into sub-categories. Some examples: Expertise may include key professionals with major interests in atypical parkinsonism, neuroimaging (PET, MRI), genetics, etc. Resources might include longitudinal clinical data, high-throughput sequence or genotype information, etc. Reagents might include inducible pluripotent cell lines (iPSCs), plasmid constructs, or mouse models for genes implicated in Parkinson’s disease.
Although there will be some overlap with other cores e.g. with the Communications core on who is a current/active GEoPD member, with the Clinical core on number of patients and control subjects for whom clinical data and DNA is available, with the Bioinformatics core on genotype/sequence information etc. It will be the Biology’s core’s responsibility to create and maintain an indexed, searchable database of biologic ‘meta-data’ for the consortium.
Core Leaders: Jan Aasly, Beom Jeon, Katerina Markopoulou, Rejko Krueger
The Clinical Core will establish a basic clinical database for all patients/controls in the consortium in an advanced REDCap based database. It integrates as a longterm project the LONG-PD study (PI: Katerina Markopoulou) that provides important data from longitudinal follow-up of PD patients.
The objective of the Clinical Core is to provide a standard dataset with basic clinical assessments that can be used by each site based on a specific access for the web-based REDCap system and will allow data sharing for upcoming projects within the consortium.
The cases collected within the clinical database will not only comprise idiopathic PD patients, but also other forms of neurodegenerative parkinsonism, i.e. PSP, MSA, CBS. Moreover the database should allow for analyses of therapeutic outcomes and integrate information on pharmacological and device-based interventional treatments, i.e. deep brain stimulation (DBS) or pumps (LCIG, apomorphine).
It will be the Clinical Core’s responsibility (i) to create a basic dataset, that is harmonized based on current state-of-the-art diagnostic criteria and clinical scores, and (ii) to maintain a comprehensive, regularly updated searchable database of clinical data for the Consortium in collaboration with the Bioinformatics Core.
Core Leaders: Matt Farrer, Christine Klein, Rejko Kruger
The Communications core is to maintain a list of active members and their contact details. It is to explicitly enable effective correspondence between sites/individuals, by whatever means is most effective, currently email, list serves and more recently via shared folders on dropbox.
Website development is to enable direct communication between members to facilitate projects and the exchange of information and resources. The Communications core will aim to provide an archive of past dialogues within projects and cores. It will also seek to archive data from past meetings, including their program and event photographs.
Core Leaders: Alexis Elbaz, George Mellick, Karin Wirdefeldt, Christina Lill
The Epidemiology and Statistics core is to maintain a list of the data available at different sites and will facilitate harmonization of data across sites.
It will monitor the epidemiological literature, with a particular interest in gene-environment interactions, and will regularly provide updates on recent findings. It will also monitor the statistical literature for relevant methods that can be used within the consortium.
Members of the consortium will also be able to consult the core for questions on study design, analysis, and presentation of results.
These Cores provide a mechanism whereby active global site investigators may share their expertise, resources and reagents. The consortium’s mission is to promote multi-investigator research projects throughout the year.
Annual Meetings offer a valuable forum for consortium members to discuss unpublished data and ideas, highlight research questions or needs and identify global opportunities for partnership.
11th Annual Meeting
October 5 - 8, 2016
The 10th Annual Meeting of GEoPD was hosted by Dr. Nobutaka Hattori.
ALPHA-SYNUCLEIN AND COGNITION IN PD
Next-generation sequence analysis of alpha-synuclein (SNCA) in Parkinson disease will test whether genetic variability is associated with motor, cognitive and neuropsychiatric disturbances, and whether it may influence susceptibility and/or decline.